The commonly accepted role for hemoglobin F is limited to facilitating diffusion through the placenta. In foetal circulation, however, at a partial oxygen pressure (pO2) of 25 mmHg in the umbilical vein, the oxygen carrier is type F hemoglobin which has a high oxygen affinity. Hemoglobin with decreased affinity for oxygen increases the oxygenation of tissues, because it gives up oxygen more easily during microcirculation. This process occurs mainly due to the increased synthesis of 2,3-diphosphoglycerate (2,3-DPG) in the erythrocytes, as well as through the Bohr effect. One of the basic mechanisms of adapting to hypoxemia is a decrease in the affinity of hemoglobin for oxygen. Kwasiborski, Przemysław Jerzy Kowalczyk, Paweł Zieliński, Jakub Przybylski, Jacek Cwetsch, Andrzej
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |